CHRNA10 blocking peptide

CHRNA10 Antibody (Center) Blocking peptide

• Synonyms: CHRNA10; CHRNA10 Antibody (Center) Blocking peptide; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10; NACHRA10; CHRNA10 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 450

• Cellular Location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein
• Tissue Location: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CHRNA10 blocking peptide

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

NCBI and Uniprot Product Information

• NCBI GI #: 14916526
• NCBI GeneID: 57053
• UniProt Accession #: Q9GZZ6
• Molecular Weight: 49,705 Da
• NCBI Official Full Name: Neuronal acetylcholine receptor subunit alpha-10
• NCBI Official Synonym Full Names: cholinergic receptor nicotinic alpha 10 subunit
• NCBI Official Symbol: CHRNA10
• NCBI Protein Information: neuronal acetylcholine receptor subunit alpha-10
• UniProt Protein Name: Neuronal acetylcholine receptor subunit alpha-10
• Protein Family: Neuronal acetylcholine receptor
• UniProt Gene Name: CHRNA10
• UniProt Synonym Gene Names: NACHRA10; NACHR alpha-10
• UniProt Entry Name: ACH10_HUMAN

Uniprot Description

nAChRA10: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 10/CHRNA10 sub-subfamily.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; nicotinic acetylcholine-gated receptor-channel complex

Molecular Function: acetylcholine binding; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; regulation of cell proliferation; synaptic transmission, cholinergic