Cdc20 blocking peptide

Cdc20 (Q105) Peptide

Cat. Num. AAA3002284

• Gene Names: CDC20; CDC20A; p55CDC; bA276H19.3
• Applications: Blocking
• Purity: Synthetic peptide Cdc20 (Q105). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Cdc20; Cdc20 (Q105) Peptide; Cell division cycle protein 20 homolog; p55CDC; CDC20; Cdc20 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002283 Cdc20 (Q105) pAb.
• Purity/Purification: Synthetic peptide Cdc20 (Q105). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 499

• Applicable Applications for Cdc20 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for Cdc20 blocking peptide

Transition from G1 to S phase requires the association of Cdc28 with members of the G1 cyclin family. Exit from mitosis and initiation of the next cell cycle requires a complex of proteins designated the anaphase-promoting complex (APC). This complex consists of two proteins, Cdc16 and Cdc27 (also referred to as Snb1), which are involved in limiting DNA replication to once per cell cycle. Cdc23, another component of the APC, is required for both entering and exiting anaphase, and is important for the proper separation of sister chromatids. The APC is thought to be stabilized by Cdc26 (also known as Scd26). In addition to these APC proteins, Cdc5 is also required for completion of mitosis. In contrast, Cdc20 acts as a DNA-damage induced checkpoint, preventing mitosis when DNA damage has occurred..

NCBI and Uniprot Product Information

• NCBI GI #: 118402582
• NCBI GeneID: 991
• NCBI Accession #: NP_001246.2
• NCBI GenBank Nucleotide #: NP_001246.2
• UniProt Accession #: Q12834
• NCBI Official Full Name: cell division cycle protein 20 homolog
• NCBI Official Synonym Full Names: cell division cycle 20
• NCBI Official Symbol: CDC20
• NCBI Official Synonym Symbols: CDC20A; p55CDC; bA276H19.3
• NCBI Protein Information: cell division cycle protein 20 homolog
• UniProt Protein Name: Cell division cycle protein 20 homolog
• Protein Family: Cell division cycle protein
• UniProt Gene Name: CDC20
• UniProt Entry Name: CDC20_HUMAN

NCBI Description

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

Uniprot Description

CDC20: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Found in a complex with CDC20, CDC27, SPATC1 and TUBG1. Interacts with SPATC1. Interacts with NEUROD2. Interacts with MAD2L1 and BUB1B. The phosphorylated form interacts with APC/C. Interacts with NINL. May interact with MAD2L2. Interacts with CDK5RAP2. Interacts with isoform 1 of NEK2. Belongs to the WD repeat CDC20/Fizzy family.

Protein type: Ubiquitin conjugating system; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleoplasm; spindle pole; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; spindle; cytosol; nucleus

Molecular Function: protein C-terminus binding; protein binding; enzyme binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of synaptic plasticity; regulation of meiosis; regulation of dendrite development; protein ubiquitination; cell cycle; anaphase-promoting complex activation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of cell proliferation; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle