CAV2 blocking peptide

CAV2 Antibody (N-term) Blocking Peptide

• Gene Names: CAV2; CAV
• Synonyms: CAV2; CAV2 Antibody (N-term) Blocking Peptide; Caveolin-2; CAV2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CAV2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 162

• Cellular Location: Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27- phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.
• Tissue Location: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CAV2 blocking peptide

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 5915890
• NCBI GeneID: 858
• UniProt Accession #: P51636; Q9UGM7; A4D0U2
• Molecular Weight: 12,780 Da
• NCBI Official Full Name: Caveolin-2
• NCBI Official Synonym Full Names: caveolin 2
• NCBI Official Symbol: CAV2
• NCBI Official Synonym Symbols: CAV
• NCBI Protein Information: caveolin-2
• UniProt Protein Name: Caveolin-2
• Protein Family: Caveolin
• UniProt Gene Name: CAV2
• UniProt Entry Name: CAV2_HUMAN

NCBI Description

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Uniprot Description

Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: caveola; cytoplasmic vesicle; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; integral to plasma membrane; intracellular; lipid raft; perinuclear region of cytoplasm; plasma membrane; protein complex; transport vesicle

Molecular Function: protein binding; protein homodimerization activity

Biological Process: endoplasmic reticulum organization and biogenesis; insulin receptor signaling pathway; mitochondrion organization and biogenesis; negative regulation of endothelial cell proliferation; positive regulation of dopamine receptor signaling pathway; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; receptor mediated endocytosis of virus by host; regulation of mitosis; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization and biogenesis