Immunohistochemistry - Paraffin (IHC)
(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
Goat CAV2 / Caveolin 2 Polyclonal Antibody | anti-CAV2 antibody
Anti-CAV2 / Caveolin 2 Antibody IHC-plus
WB (1:500 - 1:2000)
Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Immunohistochemistry - Paraffin (IHC)
(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))
Western Blot (WB)
(Anti-CAV pAb at 1:1000 dilution. 50ug lysate per lane of transfected HEK293 and 100ug of HaCat cell lysate.)
Western Blot (WB)
(Anti-CAV pAb at 1:1000 dilution. 50ug lysate per lane of transfected HEK293 and 100ug of HaCat cell lysate.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Uniprot Description
Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: acrosomal membrane; caveola; cytoplasmic vesicle; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; Golgi membrane; integral to plasma membrane; intracellular; lipid raft; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; transport vesicle
Molecular Function: D1 dopamine receptor binding; protein binding; protein binding, bridging; protein complex scaffold; protein heterodimerization activity; protein homodimerization activity; protein kinase binding
Biological Process: endoplasmic reticulum organization and biogenesis; insulin receptor signaling pathway; mitochondrion organization and biogenesis; negative regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of dopamine receptor signaling pathway; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAPKKK cascade; protein oligomerization; receptor mediated endocytosis of virus by host; regulation of mitosis; skeletal muscle fiber development; vesicle docking; vesicle fusion; vesicle organization and biogenesis
Research Articles on CAV2
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Product Notes
The CAV2 cav2 (Catalog #AAA2400077) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Anti-CAV2 / Caveolin 2 Antibody IHC-plus reacts with Mouse, Dog, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CAV2 / Caveolin 2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P (5 ug/ml) WB (1:500 - 1:2000). Researchers should empirically determine the suitability of the CAV2 cav2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAV2 / Caveolin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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