CARD9 blocking peptide

CARD9 Peptide

Cat. Num. AAA152025

• Gene Names: CARD9; CANDF2; hCARD9
• Applications: Blocking (BL)
• Synonyms: CARD9; CARD9 Peptide; CANDF2; hCARD9; Caspase recruitment domain-containing protein 9; caspase recruitment domain family; member 9; CARD9 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 2132

• Applicable Applications for CARD9 blocking peptide: Blocking (BL)
• Application Notes: CARD9 peptide is used for blocking the activity of CARD9 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids of human CARD9.
• Preparation and Storage: Store CARD9 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 11066983
• NCBI GeneID: 64170
• UniProt Accession #: Q9H257; Q5SXM5; Q5SXM6; Q9H854
• Molecular Weight: 42,953 Da
• NCBI Official Full Name: Homo sapiens caspase recruitment domain protein 9 mRNA, complete cds
• NCBI Official Synonym Full Names: caspase recruitment domain family, member 9
• NCBI Official Symbol: CARD9
• NCBI Official Synonym Symbols: CANDF2; hCARD9
• NCBI Protein Information: caspase recruitment domain-containing protein 9
• UniProt Protein Name: Caspase recruitment domain-containing protein 9
• Protein Family: Caspase recruitment domain-containing protein
• UniProt Gene Name: CARD9
• UniProt Synonym Gene Names: hCARD9
• UniProt Entry Name: CARD9_HUMAN

NCBI Description

The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

Uniprot Description

CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm

Molecular Function: protein homodimerization activity; CARD domain binding

Biological Process: response to drug; response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of tumor necrosis factor production; positive regulation of stress-activated MAPK cascade; regulation of apoptosis; defense response to Gram-positive bacterium; response to exogenous dsRNA; response to muramyl dipeptide; response to peptidoglycan; innate immune response; defense response to virus; regulation of tumor necrosis factor biosynthetic process

Disease: Candidiasis, Familial, 2