CAPN5 blocking peptide

CAPN5 Blocking Peptide (N-Term)

Gene Names

CAPN5; VRNI; ADNIV; HTRA3; nCL-3

Synonyms

CAPN5; CAPN5 Blocking Peptide (N-Term); Calpain-5; 3422-; Calpain htra-3; New calpain 3; nCL-3; NCL3; CAPN5 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 297-311 of HUMAN CAPN5

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

640

Tissue Location

Expressed in many tissues. Strong expression in the photoreceptor cells of the retina, with a punctate pattern of labeling over the nuclei and inner segments with less expression along the other segments and outer plexiform layer

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

NCBI and Uniprot Product Information

NCBI GI #

28376972

NCBI GeneID

726

UniProt Accession #

O15484; O00263

Molecular Weight

73,169 Da

NCBI Official Full Name

Calpain-5

NCBI Official Synonym Full Names

calpain 5

NCBI Official Symbol

CAPN5

NCBI Official Synonym Symbols

VRNI; ADNIV; HTRA3; nCL-3

NCBI Protein Information

calpain-5

UniProt Protein Name

Calpain-5

Protein Family

Calpain

UniProt Gene Name

CAPN5

UniProt Synonym Gene Names

NCL3; nCL-3

UniProt Entry Name

CAN5_HUMAN

NCBI Description

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

Uniprot Description

CAPN5: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.22.-; Protease

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: cell surface; cytoplasm; focal adhesion

Biological Process: signal transduction

Disease: Vitreoretinopathy, Neovascular Inflammatory

Research Articles on CAPN5

1. A novel CAPN5 (c.750G>T, p.Lys250Asn) missense mutation causes uveitis and neovascular retinal detachment.

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Product Notes

The CAPN5 capn5 (Catalog #AAA9230000) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CAPN5, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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CAPN5 blocking peptide