Camk4 blocking peptide
Mouse Camk4 Antibody (C-term) Blocking Peptide
Gene Names
Camk4; CaMKIV; AI666733; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
Synonyms
Camk4; Mouse Camk4 Antibody (C-term) Blocking Peptide; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR; Camk4 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
469
Cellular Location
Cytoplasm. Nucleus. Note: Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix.
Tissue Location
Expressed in brain and testis.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Camk4 blocking peptide
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). May be involved in spermatogenesis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
52,628 Da
NCBI Official Full Name
Calcium/calmodulin-dependent protein kinase type IV
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase IV
NCBI Official Symbol
Camk4
NCBI Official Synonym Symbols
CaMKIV; AI666733; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
NCBI Protein Information
calcium/calmodulin-dependent protein kinase type IV
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase type IV
Protein Family
UniProt Gene Name
Camk4
UniProt Synonym Gene Names
CaMK IV
UniProt Entry Name
KCC4_MOUSE
Uniprot Description
CAMK4: a protein kinase of the CAMK1 family. Implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. Two alternatively sliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.17; CAMK group; CAMK1 family
Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus
Molecular Function: calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding
Biological Process: long-term memory; myeloid dendritic cell differentiation; nerve-nerve synaptic transmission; nucleocytoplasmic transport; peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; signal transduction
Research Articles on Camk4
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Product Notes
The Camk4 camk4 (Catalog #AAA9221411) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Camk4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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