Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Calcium Sensing Receptor Blocking Peptide | CASR blocking peptide

Calcium Sensing Receptor Peptide

Gene Names
CASR; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
Applications
Immmunodepletion, Competition Assay
Synonyms
Calcium Sensing Receptor; Calcium Sensing Receptor Peptide; CAR; EIG8; FHH; FIH; GPRC2A; HHC1; Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism; NSHPT; Parathyroid Cell calcium-sensing receptor; PCAR1 antibody; CASR blocking peptide
Ordering
 
When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures.
For Research Use Only!
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (varies by lot)
Sequence Length
1078
Applicable Applications for CASR blocking peptide
Immmunodepletion, Competition Assay
Application Notes
Western Blot: 1:500
Immunogen
Synthetic peptide corresponding to amino acids 47-69 on human CASR gene.
Sequence: KDQDLKSRPESVECIRYNFRGFR
Expression
Temporal lobe, frontal lobe, parietal lobe, hippocampus, cerebellum, kidney, lung, liver, heart, skeletal muscle and placenta.
Molecular Function
GPCR, Receptor, Transducer.
Structure
Interacts with VCP, RNF19A and ARRB1.
Subcellular Location
Cell membrane; Mulipass membrane protein.
Preparation and Storage
-20 degree C for long term storage
Related Product Information for CASR blocking peptide
Antigenic Blocking Peptide extracellular calcium-sensing receptor isoform 2
Senses change in extracellular concentration of calcium channels.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
846
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
121,772 Da
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 2
NCBI Official Synonym Full Names
calcium sensing receptor
NCBI Official Symbol
CASR
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
NCBI Protein Information
extracellular calcium-sensing receptor
UniProt Protein Name
Extracellular calcium-sensing receptor
Protein Family
UniProt Gene Name
CASR
UniProt Synonym Gene Names
GPRC2A; PCAR1; CaSR; PCaR1
UniProt Entry Name
CASR_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

Uniprot Description

CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, integral; GPCR, family 3

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; phosphoinositide phospholipase C activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; G-protein coupled receptor protein signaling pathway; ossification

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I

Research Articles on CASR

1. Results suggest that the G allele and the homozygous GG genotype of the CaSR rs17251221 polymorphism are protective against ovarian cancer and represent low risk for it.

Similar Products

Calcium Sensing Receptor Antibody

Host: Rabbit
Reactivity: Human, Mouse, Rat
Predicted: Rabbit, Horse, Chicken, Cow, Dog, Chimpanzee, Macaque Monkey
Apps: ELISA, Western Blot

CASR Recombinant Protein

Host: E Coli or Yeast or Baculovirus or Mammalian Cell
Reactivity: n/a
Apps: n/a

CASR ELISA Kit

Host: n/a
Reactivity: Human
Apps: n/a

CASR Antibody

Host: Rabbit
Reactivity: Mouse, Rat, Human
Apps: Immunohistochemistry, Immunofluorescence, Western Blot, ELISA

Calcium Sensing Receptor Antibody

Host: Rabbit
Reactivity: Human, Mouse, Rat
Apps: Western Blot, Immunohistochemistry

Product Notes

The CASR casr (Catalog #AAA542550) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Calcium Sensing Receptor can be used in a range of immunoassay formats including, but not limited to, Immmunodepletion, Competition Assay. Western Blot: 1:500. Researchers should empirically determine the suitability of the CASR casr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcium Sensing Receptor, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

aaabiotech.com © 2012-2025

All rights reserved.

Contact us by

Tel: +1 (619) 604-9440 | Fax: +1 (619) 604-9440
contact@aaabiotech.com
Looking for a specific manual?
Request a Manual