CADM3 blocking peptide

CADM3 Peptide

Cat. Num. AAA154482

• Gene Names: CADM3; BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
• Applications: Blocking (BL)
• Synonyms: CADM3; CADM3 Peptide; Cell adhesion molecule 3; BIgR; NECL1; Necl-1; TSLL1; IGSF4B; synCAM3; CADM3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Positions: 16 amino acid peptide near the center of human CADM3.
• Sequence: AMIRPDPPHPREGQKL
• Sequence Length: 432

• Applicable Applications for CADM3 blocking peptide: Blocking (BL)
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Species: Human
• Preparation and Storage: Store at -20 degree C, stable for one year.

References

1. Fukuhara H, Kuramochi M, Nobukuni T, et al. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene 2001; 20:5401-7. 2. Takai Y, Mioshi J, Ikeda W, et al. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat. Rev. Mol. Cell Biol. 2008; 9:603-15. 3. Kakunaga S, Ikeda W, Itoh S, et al. Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J. Cell Sci. 2005; 118:1267-77. 4. Raveh S, Gavert N, Spiegel I, et al. The cell adhesion nectin-like (Necl) molecules 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. J. Biol. Biochem. 2009; 108:326-36.

NCBI and Uniprot Product Information

• NCBI GI #: 11056046
• NCBI GeneID: 57863
• NCBI Accession #: NP_067012
• NCBI GenBank Nucleotide #: NM_021189.4
• UniProt Accession #: Q8N126; Q8IZQ9; Q9NVJ5; Q9UJP1
• Molecular Weight: 38,326 Da
• NCBI Official Full Name: cell adhesion molecule 3 isoform 1
• NCBI Official Synonym Full Names: cell adhesion molecule 3
• NCBI Official Symbol: CADM3
• NCBI Official Synonym Symbols: BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
• NCBI Protein Information: cell adhesion molecule 3
• UniProt Protein Name: Cell adhesion molecule 3
• Protein Family: Cell adhesion molecule
• UniProt Gene Name: CADM3
• UniProt Synonym Gene Names: IGSF4B; NECL1; SYNCAM3; TSLL1; IgSF4B; NECL-1; SynCAM3; TSLL1

NCBI Description

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

Uniprot Description

CADM3: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane

Molecular Function: cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion