BCL9 blocking peptide

BCL9 Blocking Peptide (N-Term)

Gene Names

BCL9; LGS

Synonyms

BCL9; BCL9 Blocking Peptide (N-Term); B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9; Protein legless homolog; BCL9 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 272-284 of HUMAN BCL9

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

1426

Cellular Location

Nucleus.

Tissue Location

Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BCL9 blocking peptide

Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

206729930

NCBI GeneID

607

UniProt Accession #

O00512; Q5T489

Molecular Weight

149,290 Da

NCBI Official Full Name

B-cell CLL/lymphoma 9 protein

NCBI Official Synonym Full Names

B-cell CLL/lymphoma 9

NCBI Official Symbol

BCL9

NCBI Official Synonym Symbols

LGS

NCBI Protein Information

B-cell CLL/lymphoma 9 protein

UniProt Protein Name

B-cell CLL/lymphoma 9 protein

Protein Family

B-cell CLL/lymphoma 9 protein

UniProt Gene Name

BCL9

UniProt Synonym Gene Names

B-cell lymphoma 9 protein; Bcl-9

UniProt Entry Name

BCL9_HUMAN

NCBI Description

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]

Uniprot Description

Bcl-9: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity. A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. Belongs to the BCL9 family.

Protein type: Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cis-Golgi network; nucleoplasm

Molecular Function: protein binding

Biological Process: regulation of transforming growth factor beta receptor signaling pathway

Research Articles on BCL9

1. BCL9 is a molecular driver of DCIS invasive progression.

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Product Notes

The BCL9 bcl9 (Catalog #AAA9230110) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BCL9, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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BCL9 blocking peptide