B4GALT6 blocking peptide

B4GALT6 Antibody (C-term) Blocking peptide

• Gene Names: B4GALT6; B4Gal-T6; beta4Gal-T6
• Synonyms: B4GALT6; B4GALT6 Antibody (C-term) Blocking peptide; Beta-1;4-galactosyltransferase 6; Beta-1;4-GalTase 6; Beta4Gal-T6; b4Gal-T6; 241-; UDP-Gal:beta-GlcNAc beta-1;4-galactosyltransferase 6; UDP-galactose:beta-N-acetylglucosamine beta-1;4-galactosyltransferase 6; Glucosylceramide beta-1;4-galactosyltransferase; Lactosylceramide synthase; LacCer synthase; UDP-Gal:glucosylceramide beta-1;4-galactosyltransferase; B4GALT6 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 382

• Cellular Location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note: Trans cisternae of Golgi stack
• Tissue Location: High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for B4GALT6 blocking peptide

Required for the biosynthesis of glycosphingolipids.

NCBI and Uniprot Product Information

• NCBI GI #: 13123991
• NCBI GeneID: 9331
• UniProt Accession #: Q9UBX8; O60514; Q6NT09
• Molecular Weight: 40,127 Da
• NCBI Official Full Name: Beta-1,4-galactosyltransferase 6
• NCBI Official Synonym Full Names: beta-1,4-galactosyltransferase 6
• NCBI Official Symbol: B4GALT6
• NCBI Official Synonym Symbols: B4Gal-T6; beta4Gal-T6
• NCBI Protein Information: beta-1,4-galactosyltransferase 6
• UniProt Protein Name: Beta-1,4-galactosyltransferase 6
• Protein Family: Beta-1,4-galactosyltransferase
• UniProt Gene Name: B4GALT6
• UniProt Synonym Gene Names: LacCer synthase
• UniProt Entry Name: B4GT6_HUMAN

NCBI Description

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]

Uniprot Description

B4GALT6: Required for the biosynthesis of glycosphingolipids. Belongs to the glycosyltransferase 7 family.

Protein type: Membrane protein, integral; EC 2.4.1.274; Lipid Metabolism - sphingolipid; Transferase

Chromosomal Location of Human Ortholog: 18q11

Cellular Component: Golgi membrane

Molecular Function: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; galactosyltransferase activity

Biological Process: keratan sulfate biosynthetic process