Axl blocking peptide

Mouse Axl Antibody (N-term) Blocking Peptide

• Gene Names: Axl; Ark; Ufo; Tyro7; AI323647
• Synonyms: Axl; Mouse Axl Antibody (N-term) Blocking Peptide; Tyrosine-protein kinase receptor UFO; Adhesion-related kinase; Ark; Ufo; Axl blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 888

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: In distinct substructures of a broad spectrum of developing tissues (in the late embryogenesis). In cells forming organ capsules as well as in connective tissue structures (in adult)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Axl blocking peptide

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

NCBI and Uniprot Product Information

• NCBI GI #: 342187104
• NCBI GeneID: 26362
• UniProt Accession #: Q00993; Q80YQ3
• Molecular Weight: 98,191 Da
• NCBI Official Full Name: Tyrosine-protein kinase receptor UFO
• NCBI Official Synonym Full Names: AXL receptor tyrosine kinase
• NCBI Official Symbol: Axl
• NCBI Official Synonym Symbols: Ark; Ufo; Tyro7; AI323647
• NCBI Protein Information: tyrosine-protein kinase receptor UFO
• UniProt Protein Name: Tyrosine-protein kinase receptor UFO
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: Axl
• UniProt Synonym Gene Names: Ark; Ufo
• UniProt Entry Name: UFO_MOUSE

Uniprot Description

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.1; Oncoprotein; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Axl family

Cellular Component: cell surface; extracellular space

Molecular Function: myosin heavy chain binding; phosphatidylserine binding; phosphoinositide 3-kinase binding; protein heterodimerization activity; protein-tyrosine kinase activity

Biological Process: apoptotic cell clearance; blood vessel remodeling; cell differentiation; cellular response to extracellular stimulus; entry of virus into host cell; enzyme linked receptor protein signaling pathway; erythrocyte homeostasis; forebrain cell migration; inflammatory response; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptosis; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; phagocytosis; platelet activation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling cascade; protein kinase B signaling cascade; secretion by cell; spermatogenesis; vagina development