Aurka blocking peptide

Mouse Aurka Antibody (N-term) Blocking Peptide

• Gene Names: Aurka; IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; AU019385; AW539821; Aurora-A
• Synonyms: Aurka; Mouse Aurka Antibody (N-term) Blocking Peptide; Aurora kinase A; Aurora 2; Aurora family kinase 1; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A; Aurka blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 395

• Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note: Localizes on centrosomes in interphase cells and at each spindle pole in mitosis. Associates with both the pericentriolar material (PCM) and centrioles. Colocalized with SIRT2 at centrosome (By similarity). Detected at the neurite hillock in developing neurons.
• Tissue Location: Detected in embryonic neurons in dorsal root ganglia and brain cortex (at protein level). Highly expressed in testis, in about one third of the seminiferous tubules. Expression is restricted to specific spermatocytes nearing completion of prophase, with levels falling off on transition to elongated spermatids. Highly expressed in the ovary, expression in the oocyte starts around the transition to large growing follicle Abundant expression is seen in the proliferating granulosa and thecal cells of the growing follicle, and in the young corpus luteum. Very weakly expressed in spleen and intestine
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Aurka blocking peptide

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

NCBI and Uniprot Product Information

• NCBI GI #: 27923856
• NCBI GeneID: 20878
• UniProt Accession #: P97477; O35624; Q8C3H8; Q91YU4
• Molecular Weight: 47,173 Da
• NCBI Official Full Name: Aurora kinase A
• NCBI Official Synonym Full Names: aurora kinase A
• NCBI Official Symbol: Aurka
• NCBI Official Synonym Symbols: IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; AU019385; AW539821; Aurora-A
• NCBI Protein Information: aurora kinase A
• UniProt Protein Name: Aurora kinase A
• Protein Family: Aurora kinase
• UniProt Gene Name: Aurka
• UniProt Synonym Gene Names: Aik; Airk; Ark1; Aura; Ayk1; Btak; Iak1; Stk15; Stk6; ARK-1; Aurora-related kinase 1
• UniProt Entry Name: AURKA_MOUSE

Uniprot Description

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Oncoprotein; Other group; AUR family

Cellular Component: axon hillock; centrosome; condensed nuclear chromosome, pericentric region; germinal vesicle; microtubule cytoskeleton; microtubule organizing center; nucleus; perinuclear region of cytoplasm; pronucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome

Molecular Function: histone serine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding

Biological Process: anterior/posterior axis specification; centrosome localization; centrosome organization and biogenesis; meiosis; meiotic spindle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mitosis; mitotic cell cycle; mitotic centrosome separation; mitotic spindle organization and biogenesis; negative regulation of apoptosis; negative regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cytokinesis; regulation of protein stability; spindle assembly involved in female meiosis I; spindle organization and biogenesis