ATP5F1 blocking peptide

ATP5F1 Blocking Peptide (Center)

• Gene Names: ATP5F1; PIG47
• Synonyms: ATP5F1; ATP5F1 Blocking Peptide (Center); ATP synthase F(0) complex subunit B1; mitochondrial; ATP synthase proton-transporting mitochondrial F(0) complex subunit B1; ATP synthase subunit b; ATPase subunit b; ATP5F1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 181-195 of Human ATP5F1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 256

• Cellular Location: Mitochondrion. Mitochondrion inner membrane.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ATP5F1 blocking peptide

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

NCBI and Uniprot Product Information

• NCBI GI #: 20455474
• NCBI GeneID: 515
• UniProt Accession #: P24539; Q9BQ68; Q9BRU8
• Molecular Weight: 28,909 Da
• NCBI Official Full Name: ATP synthase F(0) complex subunit B1, mitochondrial
• NCBI Official Synonym Full Names: ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1
• NCBI Official Symbol: ATP5F1
• NCBI Official Synonym Symbols: PIG47
• NCBI Protein Information: ATP synthase F(0) complex subunit B1, mitochondrial
• UniProt Protein Name: ATP synthase F(0) complex subunit B1, mitochondrial
• Protein Family: ATP synthase F(0) complex
• UniProt Gene Name: ATP5F1
• UniProt Synonym Gene Names: ATPase subunit b
• UniProt Entry Name: AT5F1_HUMAN

NCBI Description

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP5F1: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the eukaryotic ATPase B chain family.

Protein type: EC 3.6.3.14; Mitochondrial; Hydrolase; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleoplasm; nucleus

Molecular Function: ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; protein binding; transmembrane transporter activity

Biological Process: ATP biosynthetic process; ATP synthesis coupled proton transport; mitochondrial ATP synthesis coupled proton transport; substantia nigra development