ARHGEF7 blocking peptide
ARHGEF7 Blocking Peptide (C-Term)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
Uniprot Description
ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.
Protein type: GEFs; GEFs, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cell soma; cytosol; focal adhesion; lamellipodium; neuron projection; protein complex
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein kinase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; focal adhesion formation; Golgi organization and biogenesis; lamellipodium biogenesis; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Research Articles on ARHGEF7
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Product Notes
The ARHGEF7 arhgef7 (Catalog #AAA9230741) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ARHGEF7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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