APOB48R blocking peptide

APOB48R Blocking Peptide

Cat. Num. AAA9620483

• Gene Names: APOBR; APOB48R; APOB100R
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: APOB48R; APOB48R Blocking Peptide; apo b-100; APOB; apoB-48R; APOBR; APOBR_HUMAN; Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; APOB48R blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for APOB48R blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for APOB48R blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 340138932
• NCBI GeneID: 55911
• NCBI Accession #: NP_061160.3
• NCBI GenBank Nucleotide #: NM_018690.3
• UniProt Accession #: Q0VD83; Q0VD81; Q8NC15; Q9NPJ9; H3BU97
• Molecular Weight: Predicted MW: 14.7 kDa; Observed MW: 17 kDa; (The reducing (R) protein migrates as xx kDa in SDS-PAGE may be due to relative charge.)
• NCBI Official Full Name: apolipoprotein B receptor
• NCBI Official Synonym Full Names: apolipoprotein B receptor
• NCBI Official Symbol: APOBR
• NCBI Official Synonym Symbols: APOB48R; APOB100R
• NCBI Protein Information: apolipoprotein B receptor
• UniProt Protein Name: Apolipoprotein B receptor
• UniProt Gene Name: APOBR
• UniProt Synonym Gene Names: APOB48R; Apolipoprotein B48 receptor; apoB-48R
• UniProt Entry Name: APOBR_HUMAN

NCBI Description

Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

APOB48R: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: chylomicron; membrane; plasma membrane

Molecular Function: very-low-density lipoprotein receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; triacylglycerol metabolic process; lipid transport