APC2 blocking peptide

APC2 Blocking Peptide (N-Term)

Gene Names

APC2; APCL

Synonyms

APC2; APC2 Blocking Peptide (N-Term); Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; APCL; APC2 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 142-152 of HUMAN APC2

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

2303

Cellular Location

Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side Note: Associated with actin filaments and the microtubule network

Tissue Location

Widely expressed (at protein level). Specifically expressed in the CNS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for APC2 blocking peptide

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.

NCBI and Uniprot Product Information

NCBI GI #

74722250

NCBI GeneID

10297

UniProt Accession #

O95996; Q05BW4; Q9UBZ1; Q9UEM8; Q9UQJ8; Q9UQJ9; Q9Y632

Molecular Weight

243,821 Da

NCBI Official Full Name

Adenomatous polyposis coli protein 2

NCBI Official Synonym Full Names

APC2, WNT signaling pathway regulator

NCBI Official Symbol

APC2

NCBI Official Synonym Symbols

APCL

NCBI Protein Information

adenomatous polyposis coli protein 2

UniProt Protein Name

Adenomatous polyposis coli protein 2

Protein Family

Acetophenone carboxylase

UniProt Gene Name

APC2

UniProt Synonym Gene Names

APCL; APC-like

UniProt Entry Name

APC2_HUMAN

Uniprot Description

APCL: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Belongs to the adenomatous polyposis coli (APC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: actin filament; beta-catenin destruction complex; catenin complex; cytoplasm; cytoplasmic microtubule; Golgi apparatus; microtubule cytoskeleton; perinuclear region of cytoplasm

Molecular Function: beta-catenin binding; gamma-catenin binding; protein binding

Biological Process: cell fate specification; cell migration; cell proliferation; negative regulation of microtubule depolymerization; pattern specification process; positive regulation of protein catabolic process; regulation of cell differentiation

Research Articles on APC2

1. The results showed that APC2 and APC7 subunits were both over expressed in cancer cell lines

Similar Products

Product Notes

The APC2 apc2 (Catalog #AAA9230454) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "APC2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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APC2 blocking peptide