AP3M1 blocking peptide

AP3M1 Antibody (C-term) Blocking Peptide

• Synonyms: AP3M1; AP3M1 Antibody (C-term) Blocking Peptide; AP-3 complex subunit mu-1; AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Mu-adaptin 3A; Mu3A-adaptin; AP3M1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 418

• Cellular Location: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AP3M1 blocking peptide

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

NCBI and Uniprot Product Information

• NCBI GI #: 13123952
• NCBI GeneID: 26985
• UniProt Accession #: Q9Y2T2; Q5JQ12; Q9H5L2
• Molecular Weight: 46,939 Da
• NCBI Official Full Name: AP-3 complex subunit mu-1
• NCBI Official Synonym Full Names: adaptor related protein complex 3 mu 1 subunit
• NCBI Official Symbol: AP3M1
• NCBI Protein Information: AP-3 complex subunit mu-1
• UniProt Protein Name: AP-3 complex subunit mu-1
• Protein Family: AP-3 complex
• UniProt Gene Name: AP3M1
• UniProt Entry Name: AP3M1_HUMAN

NCBI Description

The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

AP3M1: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: lysosomal membrane; lysosome

Molecular Function: protein binding; Rab GTPase binding

Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; protein targeting to lysosome