AP1G2 blocking peptide

AP1G2 Antibody (N-term) Blocking peptide

• Gene Names: AP1G2; G2AD
• Synonyms: AP1G2; AP1G2 Antibody (N-term) Blocking peptide; AP-1 complex subunit gamma-like 2; Gamma2-adaptin; G2ad; AP1G2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of AP1G2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 785

• Cellular Location: Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein Note: Mainly localized to perinuclear vesicular structures Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments. Colocalizes with HBV major surface antigen L to cis-Golgi-like structures
• Tissue Location: Expressed in all but one (skeletal muscle) tissues examined
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AP1G2 blocking peptide

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

NCBI and Uniprot Product Information

• NCBI GI #: 12643299
• NCBI GeneID: 8906
• UniProt Accession #: O75843; O75504; D3DS51
• Molecular Weight: 87,117 Da
• NCBI Official Full Name: AP-1 complex subunit gamma-like 2
• NCBI Official Synonym Full Names: adaptor related protein complex 1 gamma 2 subunit
• NCBI Official Symbol: AP1G2
• NCBI Official Synonym Symbols: G2AD
• NCBI Protein Information: AP-1 complex subunit gamma-like 2
• UniProt Protein Name: AP-1 complex subunit gamma-like 2
• Protein Family: AP-1 complex
• UniProt Gene Name: AP1G2
• UniProt Synonym Gene Names: G2ad
• UniProt Entry Name: AP1G2_HUMAN

NCBI Description

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Uniprot Description

AP1G2: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). Belongs to the adaptor complexes large subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: AP-1 adaptor complex; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; membrane; transport vesicle

Molecular Function: protein binding