AMICA1 blocking peptide

AMICA1 Antibody (N-term) Blocking Peptide

• Gene Names: JAML; AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
• Synonyms: AMICA1; AMICA1 Antibody (N-term) Blocking Peptide; Junctional adhesion molecule-like; Adhesion molecule interacting with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; JAML; AMICA1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 394

• Cellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction. Note: Localized at the plasma membrane and enriched in areas of cell-cell contacts
• Tissue Location: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AMICA1 blocking peptide

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

NCBI and Uniprot Product Information

• NCBI GI #: 71151910
• NCBI GeneID: 120425
• UniProt Accession #: Q86YT9; Q496M1; Q5DTC6; Q7Z499; Q8N9I7; Q8NF70; B0YIV1; B0YIV2
• Molecular Weight: 40,136 Da
• NCBI Official Full Name: Junctional adhesion molecule-like
• NCBI Official Synonym Full Names: junction adhesion molecule like
• NCBI Official Symbol: JAML
• NCBI Official Synonym Symbols: AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
• NCBI Protein Information: junctional adhesion molecule-like
• UniProt Protein Name: Junctional adhesion molecule-like
• UniProt Gene Name: JAML
• UniProt Entry Name: JAML_HUMAN

Uniprot Description

AMICA1: an adhesion molecule that may function in the migration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. Three alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: plasma membrane; tight junction

Molecular Function: cell adhesion molecule binding; integrin binding; protein homodimerization activity

Biological Process: gamma-delta T cell activation; heterophilic cell adhesion; leukocyte migration; neutrophil chemotaxis; positive regulation of epithelial cell proliferation involved in wound healing; regulation of immune response