Aldolase (ALDOA) Blocking Peptide | ALDOA blocking peptide

Aldolase (ALDOA) Antibody (N-term) Blocking peptide

• Gene Names: ALDOA; ALDA; GSD12; HEL-S-87p
• Synonyms: Aldolase (ALDOA); Aldolase (ALDOA) Antibody (N-term) Blocking peptide; Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase; ALDOA; ALDA; ALDOA blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human ALDOA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 364

• Cellular Location: Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Note: In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ALDOA blocking peptide

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 113606
• NCBI GeneID: 226
• UniProt Accession #: P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2; B4DXI7
• Molecular Weight: 45,261 Da
• NCBI Official Full Name: Fructose-bisphosphate aldolase A
• NCBI Official Synonym Full Names: aldolase, fructose-bisphosphate A
• NCBI Official Symbol: ALDOA
• NCBI Official Synonym Symbols: ALDA; GSD12; HEL-S-87p
• NCBI Protein Information: fructose-bisphosphate aldolase A
• UniProt Protein Name: Fructose-bisphosphate aldolase A
• Protein Family: Fructose-bisphosphate aldolase
• UniProt Gene Name: ALDOA
• UniProt Synonym Gene Names: ALDA
• UniProt Entry Name: ALDOA_HUMAN

NCBI Description

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]

Uniprot Description

ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Protein type: EC 4.1.2.13; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase; Mitochondrial

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: actin cytoskeleton; cytosol; extracellular region; extracellular space; I band; membrane; nucleus

Molecular Function: actin binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; identical protein binding; protein binding; tubulin binding

Biological Process: actin filament organization; ATP biosynthetic process; fructose 1,6-bisphosphate metabolic process; fructose metabolic process; gluconeogenesis; glycolysis; muscle maintenance; platelet degranulation; protein homotetramerization; regulation of cell shape; striated muscle contraction

Disease: Glycogen Storage Disease Xii