AKTIP blocking peptide

AKTIP Antibody(C-term) Blocking peptide

• Gene Names: AKTIP; FT1; FTS
• Synonyms: AKTIP; AKTIP Antibody(C-term) Blocking peptide; AKT-interacting protein; Ft1; Fused toes protein homolog; FTS; AKTIP blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 292

• Cellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AKTIP blocking peptide

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

NCBI and Uniprot Product Information

• NCBI GI #: 54035954
• NCBI GeneID: 64400
• UniProt Accession #: Q9H8T0; Q503B1; Q53H38
• Molecular Weight: 33,256 Da
• NCBI Official Full Name: AKT-interacting protein
• NCBI Official Synonym Full Names: AKT interacting protein
• NCBI Official Symbol: AKTIP
• NCBI Official Synonym Symbols: FT1; FTS
• NCBI Protein Information: AKT-interacting protein
• UniProt Protein Name: AKT-interacting protein
• Protein Family: AKT-interacting protein
• UniProt Gene Name: AKTIP
• UniProt Synonym Gene Names: FTS
• UniProt Entry Name: AKTIP_HUMAN

NCBI Description

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

AKTIP: an oncogenic membrane-associated protein that is a component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Apparently interacts with AKT1. A member of the ubiquitin-conjugating enzyme family, FTS subfamily. Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, peripheral; Vesicle

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: cytoplasm; Golgi apparatus; nucleolus; plasma membrane

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: early endosome to late endosome transport; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding