AKAP5 blocking peptide

AKAP5 Antibody (Center) Blocking Peptide

• Gene Names: AKAP5; H21; AKAP75; AKAP79
• Synonyms: AKAP5; AKAP5 Antibody (Center) Blocking Peptide; A-kinase anchor protein 5; AKAP-5; A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; AKAP79; AKAP5 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 427

• Cellular Location: Membrane; Lipid-anchor. Note: Associates with lipid rafts
• Tissue Location: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AKAP5 blocking peptide

May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.

NCBI and Uniprot Product Information

• NCBI GI #: 281185503
• NCBI GeneID: 9495
• UniProt Accession #: P24588; A2RRB8
• Molecular Weight: 47,088 Da
• NCBI Official Full Name: A-kinase anchor protein 5
• NCBI Official Synonym Full Names: A-kinase anchoring protein 5
• NCBI Official Symbol: AKAP5
• NCBI Official Synonym Symbols: H21; AKAP75; AKAP79
• NCBI Protein Information: A-kinase anchor protein 5
• UniProt Protein Name: A-kinase anchor protein 5
• Protein Family: A-kinase anchor protein
• UniProt Gene Name: AKAP5
• UniProt Synonym Gene Names: AKAP79; AKAP-5; AKAP 79
• UniProt Entry Name: AKAP5_HUMAN

NCBI Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

Uniprot Description

AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: cytosol; plasma membrane

Molecular Function: adenylate cyclase binding; protein binding; protein kinase A binding

Biological Process: positive regulation of cAMP biosynthetic process; synaptic transmission