ABT1 blocking peptide

ABT1 Blocking Peptide (C-term)

• Gene Names: ABT1; hABT1
• Synonyms: ABT1; ABT1 Blocking Peptide (C-term); Activator of basal transcription 1; hABT1; Basal transcriptional activator; ABT1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 259-272 of HUMAN ABT1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 272

• Cellular Location: Nucleus. Nucleus, nucleolus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ABT1 blocking peptide

Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 74753396
• NCBI GeneID: 29777
• UniProt Accession #: Q9ULW3
• Molecular Weight: 31,079 Da
• NCBI Official Full Name: Activator of basal transcription 1
• NCBI Official Synonym Full Names: activator of basal transcription 1
• NCBI Official Symbol: ABT1
• NCBI Official Synonym Symbols: hABT1
• NCBI Protein Information: activator of basal transcription 1
• UniProt Protein Name: Activator of basal transcription 1
• Protein Family: Activator of basal transcription
• UniProt Gene Name: ABT1
• UniProt Synonym Gene Names: hABT1
• UniProt Entry Name: ABT1_HUMAN

NCBI Description

Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]

Uniprot Description

ABT1: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes. Belongs to the ESF2/ABP1 family.

Protein type: Nucleolus; Transcription factor; RNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: nucleolus; nucleus

Molecular Function: protein binding; RNA binding; transcription coactivator activity

Biological Process: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)