Structure
UCN-01 Biochemical
UCN-01
Purity
>98% (HPLC)
Synonyms
UCN-01; 7-Hydroxystaurosporine; NSC 638850; UCN-01 biochemical
Purity/Purification
>98% (HPLC)
Target
PKC
Receptor
PKC
Chemical Name
(3R, 9S, 10R, 11R, 13R)-2, 3, 10, 11, 12, 13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9, 13-epoxy-1H, 9H-diindolo[1, 2, 3-gh:3', 2', 1'-lm]pyrrolo[3, 4-j][1, 7]benzodiazonin-1-one
SMILES
O=C(C[C@@H](O)C=C12)C1=C3C4=CN=CC4=C5C6=C3N2C/C=C[C@@](O7)(C)[C@@H](OC)[N@@]6(NC)C8=C5C=C[C@@]7([H])C8
Molecular Formula
C28H26N4O4
CAS Number
112953-11-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for UCN-01 biochemical
UCN-01 (7-Hydroxystaurosporine; NSC 638850) is a synthetic derivative of staurosporine that has antiproliferative activity against several in vitro and in vivo cancer models; inhibits a variety of kinases, including Akt, PKC (IC50=30nM), PDK1 (IC50=6nM), CDKs (IC50=300-600nM for Cdk1 and Cdk2); arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by Chk1 (IC50=7nM); induces apoptosis.
Product Categories/Family for UCN-01 biochemical
References
1. Kawabe T. Mol Cancer Ther. 2004 Apr; 3 (4):513-9.
2. Peifer C, et al. ChemMedChem. 2008 Dec; 3 (12):1810-38.
3. Facchinetti MM, et al. Cancer Res. 2004 May 15; 64 (10):3629-37.
2. Peifer C, et al. ChemMedChem. 2008 Dec; 3 (12):1810-38.
3. Facchinetti MM, et al. Cancer Res. 2004 May 15; 64 (10):3629-37.
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Product Notes
The UCN-01 (Catalog #AAA3600455) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UCN-01, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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