Structure
UBCS039 Biochemical
UBCS039
Purity
>98% (HPLC)
Synonyms
UBCS039; UBCS-039; UBCS 039; UBCS039 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 125mg/mL (505.48mM)
Target
Sirtuin
Receptor
Sirtuin
Chemical Name
4-(pyridin-3-yl)-4, 5-dihydropyrrolo[1, 2-a]quinoxaline
SMILES
N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
Molecular Formula
C16H13N3
CAS Number
358721-70-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for UBCS039 biochemical
UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38uM; shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities; induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.
Product Categories/Family for UBCS039 biochemical
References
1. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19; 56 (4):1007-1011.
2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24; 9 (10):996.
2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24; 9 (10):996.
Similar Products
Product Notes
The UBCS039 (Catalog #AAA3604232) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UBCS039, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
