Structure
PAC-1 biochemical
PAC-1
Purity
>=95% by HPLC
Synonyms
PAC-1; 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid; PAC-1 biochemical
Purity/Purification
>=95% by HPLC
Form/Format
Appearance: White solid
Sequence Length
1563
CAS Number
315183-21-2
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD03302441
PubChem CID
6851947
Solubility/Reconstitution Instructions
DMSO
SMILES
C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O
InChi
InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2,(H,25,28)/b21-16-
InChi Key
XSGXRYNZNGUGEJ-PGMHBOJBSA-N
Handling
Protect from air and light
Preparation and Storage
4 degree C
Shelf Life: 24 months
Shelf Life: 24 months
Structure
Structure
Related Product Information for PAC-1 biochemical
Background: Procaspase-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an IC?? value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had IC?? values of 3.2-8.5 uM.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
392.49
NCBI Official Full Name
PAC-1, isoform f
NCBI Official Symbol
pac-1
NCBI Protein Information
PAC-1
UniProt Protein Name
GTPase-activating protein pac-1
Protein Family
UniProt Gene Name
pac-1
UniProt Synonym Gene Names
gap; CeGAP
UniProt Entry Name
PAC1_CAEEL
Uniprot Description
GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60 (PubMed:18583611, PubMed:8288633). Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6 (PubMed:18583611, PubMed:8288633, PubMed:25938815). Required for blastomere polarization (PubMed:25938815).
Research Articles on PAC-1
Similar Products
Product Notes
The PAC-1 pac-1 (Catalog #AAA843053) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PAC-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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