Structure
OHM1 Biochemical
OHM1
Purity
>98% (HPLC)
Synonyms
OHM1; OHM 1; OHM1 biochemical
Purity/Purification
>98% (HPLC)
Target
HIF/HIF Prolyl-hydroxylase
Receptor
HIF/HIF Prolyl-hydroxylase
Chemical Name
(S)-2-((S)-4-((S)-2-((S)-3-isobutyl-2-oxopiperazin-1-yl)-4-methylpentanoyl)-3-methyl-2-oxopiperazin-1-yl)pentanediamide
Molecular Formula
C24H42N6O5
CAS Number
1450995-09-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for OHM1 biochemical
OHM1 is a potent HIF1alpha mimic that binds to CH1 domain of p300/CBP with Kd of 500nM, reduces the level of HIF1alpha transcriptional activity under hypoxia to that observed under normoxia at 20uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.
Product Categories/Family for OHM1 biochemical
References
1. Arkin MR, et al. Chem Biol. 2014 Sep 18; 21 (9):1102-14.
2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27; 111 (21):7531-6.
3. Fang Y, et al. Exp Cell Res. 2007 Mar 10; 313 (5):867-77.
2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27; 111 (21):7531-6.
3. Fang Y, et al. Exp Cell Res. 2007 Mar 10; 313 (5):867-77.
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Product Notes
The OHM1 (Catalog #AAA3601943) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OHM1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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