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Structure

MIDD0301 Biochemical

MIDD0301

Purity
>98% (HPLC)
Synonyms
MIDD0301; MIDD 0301; MIDD-0301; MIDD0301 biochemical
Ordering
Purity/Purification
>98% (HPLC)
Target
GAT
Receptor
GAT
Chemical Name
(R)-8-bromo-6-(2-fluorophenyl)-4-methyl-4H-benzo[f]imidazo[1, 5-a][1, 4]diazepine-3-carboxylic acid
Molecular Formula
C19H13BrFN3O2
CAS Number
2187489-08-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for MIDD0301 biochemical
MIDD0301 is a potent, positive allosteric, alpha5beta3gamma2 selective, GABAA receptor (GABAAR) ligand with EC50 of 17nM, shows no significant binding at the peripheral GABAAR at 10uM; causes amplification of GABA induced current mediated by alpha1-3, 5beta3gamma2 GABAARs in the presence of MIDD0301 in automated patch clamp test; relaxes airway smooth muscle at single micromolar concentrations as demonstrated with ex vivo guinea pig tracheal rings, also attenuates airway hyperresponsiveness (AHR) in an ovalbumin murine model of asthma by oral administration, with low brain distribution; reduces lung cytokine expression of IL-17A, IL-4, and TNF-alpha, as wells as the number of CD4+ T cells.
Product Categories/Family for MIDD0301 biochemical
References
1. Forkuo GS, et al. Mol Pharm. 2018 Apr 2. doi: 10.1021/acs.molpharmaceut.7b01013.

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Product Notes

The MIDD0301 (Catalog #AAA3603489) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MIDD0301, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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