Structure
ONO-8590580 Biochemical
ONO-8590580
Purity
>98% (HPLC)
Synonyms
ONO-8590580; ONO8590580; ONO-8590580 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 62.5mg/mL (166.03mM)
Target
GAT
Receptor
GAT
Chemical Name
1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine
SMILES
CN1C=C(C2=CN=C(NC3=C(F)C(C)=C4C(N(CC5CC5)C=N4)=C3)C=C2)N=C1
Molecular Formula
C21H21FN6
CAS Number
1802661-73-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ONO-8590580 biochemical
ONO-8590580 is a novel potent, selective GABAA alpha5 negative allosteric modulator, binds to the benzodiazepine binding sites on recombinant human alpha5-containing GABAA receptors with Ki of 7.9nM; shows functionally selective GABAA alpha5 NAM activity for GABA-induced Cl- channel activity with a maximum 44.4% inhibition and an EC50 of 1.1nM; significantly augments tetanus-induced long-term potentiation of CA1 synapse response in rat hippocampal slices at 300nM; significantly prevents MK-801-induced memory deficit in vivo (3-20mg/kg, p. O.).
Product Categories/Family for ONO-8590580 biochemical
References
1. Kawaharada S, et al. J Pharmacol Exp Ther. 2018 Apr 19. pii: jpet.117.247627.
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Product Notes
The ONO-8590580 (Catalog #AAA3602753) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ONO-8590580, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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