Structure
LX-2343 Biochemical
LX-2343
Purity
>=98% by HPLC
Synonyms
LX-2343; N- (benzo[d][1; 3]dioxol-5-yl)-2- (N- (5-chloro-2-methoxyphenyl) phenylsulfonamido) acetamide; LX-2343 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Solubility
DMSO
Molecular Formula
C??H??ClN?O?S
CAS Number
333745-53-2
PubChem CID
1000980
SMILES
COC1=C (C=C (C=C1)Cl)N (CC (=O)NC2=CC3=C (C=C2)OCO3)S (=O)(=O)C4=CC=CC=C4
InChi
InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15 (23)11-18 (19)25 (32 (27,28)17-5-3-2-4-6-17)13-22 (26)24-16-8-10-20-21 (12-16)31-14-30-20/h2-12H,13-14H2,1H3, (H,24,26)
InChi Key
ZGYSGIYKAVUVOR-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Protect from air and light
Shelf life: ~36 months
Structure
Structure
Related Product Information for LX-2343 biochemical
LX-2343 is a neuroprotective agent for the treatment of Alzheimer's disease. LX2343 ameliorates cognitive dysfunction in APP/PS1 transgenic mice via both Abeta production inhibition and clearance promotion. LX2-343 dose-dependently decreases Abeta accumulation in HEK293-APPsw and CHO-APP cells,and promotes Abeta clearance in SH-SY5Y cells and primary astrocytes. The anti-amyloid effects of LX2343 are attributed to suppressing JNK-mediated APPThr668 phosphorylation, thus inhibiting APP cleavage on one hand, and inhibiting BACE1 enzymatic activity with an IC50 value of 11.43+/-0.36 umol/L, on the other hand.
Product Categories/Family for LX-2343 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/1000980
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Product Notes
The LX-2343 (Catalog #AAA848407) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LX-2343, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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