Structure
LAF389 Biochemical
LAF389
Purity
>98% (HPLC)
Synonyms
LAF389; LAF-389; LAF 389; LAF389 biochemical
Purity/Purification
>98% (HPLC)
Target
Aminopeptidase
Receptor
Aminopeptidase
Chemical Name
[(3R, 6S)-7-oxo-6-[[(E, 2R, 3R, 4S, 5R)-3, 4, 5-trihydroxy-2-methoxy-8, 8-dimethylnon-6-enoyl]amino]azepan-3-yl] cyclohexanecarboxylate
SMILES
CC(C)(C)C=CC(C(C(C(C(=O)NC1CCC(CNC1=O)OC(=O)C2CCCCC2)OC)O)O)O
Molecular Formula
C25H42N2O8
CAS Number
270902-51-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LAF389 biochemical
LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800nM for MetAP-2, inhibits both MetAp1 and 2, potently inhibits HUVEC proliferation with IC50 of 20nM; demonstrates both antiproliferative and antiangiogenetic properties, and preclinical investigations showed a broad antitumour activity. Blood CancerPhase 1 Discontinued
Product Categories/Family for LAF389 biochemical
References
1. Kinder FR Jr, et al. J Med Chem. 2001 Oct 25; 44 (22):3692-9.
2. Towbin H, et al. J Biol Chem. 2003 Dec 26; 278 (52):52964-71.
3. Kim S, et al. Cancer Res. 2004 May 1; 64 (9):2984-7.
4. Dumez H, et al. Anticancer Drugs. 2007 Feb; 18 (2):219-25.
2. Towbin H, et al. J Biol Chem. 2003 Dec 26; 278 (52):52964-71.
3. Kim S, et al. Cancer Res. 2004 May 1; 64 (9):2984-7.
4. Dumez H, et al. Anticancer Drugs. 2007 Feb; 18 (2):219-25.
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Product Notes
The LAF389 (Catalog #AAA3603826) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LAF389, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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