Structure
KW-2449 biochemical
KW-2449 hydrochloride
Purity
>=98% by HPLC
Synonyms
KW-2449; KW-2449 hydrochloride; [4-[2- (1H-Indazol-3-yl) ethenyl]phenyl]-1-piperazinylmethanone; KW-2449 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Salt Form
Yes
CAS Number
1000669-72-6
Cell-Permeable
Yes
Reconstitution
DMSO (>30 mg/ml)
SMILES
C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43
InChi
InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
InChi Key
YYLKKYCXAOBSRM-JXMROGBWSA-N
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Protect from air and light.
Structure
Structure
Related Product Information for KW-2449 biochemical
KW 2449 is a multikinase inhibitor of FLT3; ABL; ABL-T315I; and Aurora kinase. It displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase. This leads in the down-regulation of phosphorylated-FLT3/STAT5; G1 arrest; and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3; G2/M arrest; and apoptosis in FLT3 wild-type human leukemia.
Similar Products
Product Notes
The KW-2449 (Catalog #AAA846350) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KW-2449, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
