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Structure

JTV-519 fumarate Biochemical

JTV-519 fumarate

Purity
>98% (HPLC)
Synonyms
JTV-519 fumarate; K201; JTV519; JTV-519 fumarate biochemical
Ordering
Purity/Purification
>98% (HPLC)
Target
Calcium Channel
Receptor
Calcium Channel
Chemical Name
1-(2, 3-Dihydro-7-methoxy-1, 4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
Molecular Formula
C29H36N2O6S
CAS Number
1883549-36-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Structure
Related Product Information for JTV-519 fumarate biochemical
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs); displays Ca (2+)-dependent inhibition of SERCA-dependent ATPase activity with IC50 of 9uM at 0.25 Ca2+ in cardiac muscle; may prevent abnormal Ca (2+) leak from the sarcoplasmic reticulum (SR) in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors (RyRs; RyR1 and RyR2, respectively). Heart Arrhythmia Phase 2 Discontinued
Product Categories/Family for JTV-519 fumarate biochemical
References
1. Darcy YL, et al. Mol Pharmacol. 2016 Aug; 90 (2):106-15.
2. Inagaki K, et al. Circulation. 2000 Feb 22; 101 (7):797-804.
3. Ito K, et al. Br J Pharmacol. 2000 Jun; 130 (4):767-76.
4. Nakaya H, et al. Br J Pharmacol. 2000 Dec; 131 (7):1363-72.

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Product Notes

The JTV-519 fumarate (Catalog #AAA3602934) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JTV-519 fumarate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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