Structure
(Structure of H1000|Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl))
HA1077 Biochemical
HA1077 (Fasudil, 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl, 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl)
Purity
Highly Purified~90%
Synonyms
HA1077; HA1077 (Fasudil; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1; 4-diazepine•2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl); HA1077 biochemical
Purity/Purification
Highly Purified
~90%
~90%
CAS Number
103745-39-7
Molecular Formula
C14H19Cl2N3O2S• 2HCl
Melting Point
>225º
Method for Determining Identity
Proton NMR Spectroscopic Analysis;
Conforms to structure
Conforms to structure
Solubility
Methanol, Water
TLC Conditions
SiO2; Dichloromethane: Methanol: Acetic Acid; 8:2:1; Visualized with UV and ninhydrin; Rf=0.3
Chloride content: 19.3%
Chloride content: 19.3%
Preparation and Storage
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Structure
(Structure of H1000|Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl))
Structure
(Structure of H1000|Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl))
Related Product Information for HA1077 biochemical
A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).
HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK.
HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK.
Product Categories/Family for HA1077 biochemical
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Product Notes
The HA1077 (Catalog #AAA6061756) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HA1077, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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