Structure
Galiellactone Biochemical
Galiellactone
Purity
>95%
Synonyms
Galiellactone; (7bS)-?5; ?5aR; ?6; ?7; ?7aR; ?7b-?hexahydro-?7b-?hydroxy-?4S-?methyl-?indeno[1; ?7-?bc]furan-?2(4H)-?one; NSC645020; NSC-645020; Galiellactone biochemical
Purity/Purification
>95%
Form/Format
Appearance: A white lyophilized solid
CAS Number
133613-71-5
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
PubChem CID
6711856
Solubility/Reconstitution Instructions
DMSO
SMILES
CC1CC2CCC3C2(C(=C1)C(=O)O3)O
InChi
InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m1/s1
InChi Key
SOIISBQQYAGDKM-VFYMIVFZSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Shelf Life: 36 months
Structure
Structure
Related Product Information for Galiellactone biochemical
Background: Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC?? = 0.25-0.5 muM). The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 muM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.
Product Categories/Family for Galiellactone biochemical
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Product Notes
The Galiellactone (Catalog #AAA843068) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Galiellactone, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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