Structure
Etacrynic acid Biochemical
Etacrynic acid
Purity
>98% (HPLC)
Synonyms
Etacrynic acid; Edecrin; Etacrynic acid biochemical
Purity/Purification
>98% (HPLC)
Suitability
Ethanol: 30mg/mL
DMSO: 30mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
DMSO: 30mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
MEK
Receptor
NKCC2; GST
Chemical Name
Acetic acid, [2, 3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-(9CI)
SMILES
CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
Molecular Formula
C13H12Cl2O4
CAS Number
58-54-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Etacrynic acid biochemical
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling. Other Indication Phase 2 Clinical
Product Categories/Family for Etacrynic acid biochemical
References
1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2; 139 (30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15; 18 (24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1; 21 (3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6; 7 (36):58038-58050.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15; 18 (24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1; 21 (3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6; 7 (36):58038-58050.
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Product Notes
The Etacrynic acid (Catalog #AAA3605147) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Etacrynic acid, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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