Structure
Entrectinib Biochemical
Entrectinib
Purity
>98% (HPLC)
Synonyms
Entrectinib; NMS-E628; RXDX-101;nMS-01191372; Entrectinib biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=31mg/mL
Target
Trk Receptor
Receptor
ALK; ROS1; TrkA; TrkB; TrkC
Chemical Name
Benzamide, N-[5-[(3, 5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]
SMILES
O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=CC=C(N5CCN(C)CC5)C=C4NC6CCOCC6
Molecular Formula
C31H34F2N6O2
CAS Number
1108743-60-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Entrectinib biochemical
Entrectinib (NMS-E628, RXDX-101,nMS-01191372) is a potent, ATP-competitive, orally available pan-TRK, ROS1 and ALK inhibitor with IC50 of 1/3/5/12/7nM for TRKA/TRKB/TRKC/ALK/ROS1, respectively; exhibits high antiproliferative activity against colorectal carcinoma cell line KM12 with IC50 of 17nM, abolishes autophosphorylation of TPM3-TRKA, concomitant with complete inhibition of the phosphorylation of PLCgamma1, AKT, and MAPK; induces regression in relevant human xenograft tumors, including the TRKA-dependent colorectal carcinoma KM12, ROS1-driven tumors, and several ALK-dependent models. Lung Cancer Phase 2 Clinical
Product Categories/Family for Entrectinib biochemical
References
1. Menichincheri M, et al. J Med Chem. 2016 Apr 14; 59 (7):3392-408.
2. Ardini E, et al. Mol Cancer Ther. 2016 Apr; 15 (4):628-39.
3. Rolfo C, et al. Expert Opin Investig Drugs. 2015; 24 (11):1493-500.
4. Russo M, et al. Cancer Discov. 2016 Jan; 6 (1):36-44.
2. Ardini E, et al. Mol Cancer Ther. 2016 Apr; 15 (4):628-39.
3. Rolfo C, et al. Expert Opin Investig Drugs. 2015; 24 (11):1493-500.
4. Russo M, et al. Cancer Discov. 2016 Jan; 6 (1):36-44.
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Product Notes
The Entrectinib (Catalog #AAA3600406) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Entrectinib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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