Structure
(Structure of D9099-44.)
Doxorubicin, Hydrochloride Biochemical
Doxorubicin, Hydrochloride (Adriacin, Adriblastina, Adriamycin, Caelyx)
Purity
~90%
Synonyms
Doxorubicin; Hydrochloride; Hydrochloride (Adriacin; Adriblastina; Adriamycin; Caelyx); Hydrochloride biochemical
Purity/Purification
~90%
Form/Format
Supplied as an orange-red solid
CAS Number
25316-40-9
Molecular Formula
C27H29NO11• HCl
Atmosphere
Argon
Melting Point
198-203ºC
Solubility
Methanol: Water (1:1), Water
Preparation and Storage
May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic and light sensitive.
Structure
(Structure of D9099-44.)
Structure
(Structure of D9099-44.)
Related Product Information for Doxorubicin, Hydrochloride biochemical
The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.
Product Categories/Family for Doxorubicin, Hydrochloride biochemical
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Product Notes
The Doxorubicin, Hydrochloride (Catalog #AAA6117812) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Doxorubicin, Hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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