Structure
CYC065 Biochemical
CYC065
Purity
>98% (HPLC)
Synonyms
CYC065; CYC-065; CYC 065; CYC065 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=100mg/mL (251.56mM)
Target
CDK
Receptor
CDK
Chemical Name
(2R, 3S)-3-[[6-[(4, 6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
SMILES
CCC(C(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=C(C=C3C)C
Molecular Formula
C21H31N7O
CAS Number
1070790-89-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CYC065 biochemical
CYC065 is a derivative of seliciclib and second generation CDK inhibitor that is mainly active on CDK2/5/9; demonstrates cytotoxicity both in MM cell lines sensitive as well as resistant to conventional chemotherapy with IC50 of 0.06-2uM; blocks cells in the G1 phase and inhibits cell growth specifically in CCNE1-overexpressing USCs; significantly reduces tumour growth in xenografts derived from CCNE1-amplified USCs, shows synergistic effect in vitro and in vivo combined with Taselisib. Brain Cancer Phase 1 Clinical
Product Categories/Family for CYC065 biochemical
References
1. Cocco E, et al. Br J Cancer. 2016 Jul 26; 115 (3):303-11.
2. Kawakami M, et al. J Natl Cancer Inst. 2017 Jun 1; 109 (6).
3. Thomas AL, et al. Cell Cycle. 2017 Aug 3; 16 (15):1453-1464.
4. Rao SS, et al. Oncotarget. 2017 Aug 10; 8 (48):83925-83939.
2. Kawakami M, et al. J Natl Cancer Inst. 2017 Jun 1; 109 (6).
3. Thomas AL, et al. Cell Cycle. 2017 Aug 3; 16 (15):1453-1464.
4. Rao SS, et al. Oncotarget. 2017 Aug 10; 8 (48):83925-83939.
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Product Notes
The CYC065 (Catalog #AAA3600291) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CYC065, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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