Structure
Crisdesalazine Biochemical
Crisdesalazine
Purity
>98% (HPLC)
Synonyms
Crisdesalazine; AAD-2004; AAD2004; Crisdesalazine biochemical
Purity/Purification
>98% (HPLC)
Target
PGE synthase
Receptor
PGE synthase
Chemical Name
2-hydroxy-5-({2-[4-(trifluoromethyl)phenyl]ethyl}amino)benzoic acid
SMILES
O=C(O)C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O
Molecular Formula
C16H14F3NO3
CAS Number
927685-43-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Crisdesalazine biochemical
Crisdesalazine (AAD-2004, AAD2004) is a derivative of aspirin that inhibits microsomal PGE (2) synthase-1 (mPGES-1) activity in response to both LPS-treated BV2 cell with IC50 of 230nM and recombinant human mPGES-1 protein with IC50 of 249nM in vitro; blocked free radical production, PGE (2) formation, and microglial activation in the spinal cords in superoxide dismutase 1 (G93A) transgenic mouse model of ALS, reduced autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span, which is superior to riluzole or ibuprofen. Alzheimer Disease Phase 1 Clinical
Product Categories/Family for Crisdesalazine biochemical
References
1. Shin JH, et al. J Neurochem. 2012 Sep; 122 (5):952-61.
2. Baek IS, et al. Exp Neurobiol. 2013 Mar; 22 (1):31-7.
2. Baek IS, et al. Exp Neurobiol. 2013 Mar; 22 (1):31-7.
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Product Notes
The Crisdesalazine (Catalog #AAA3606634) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Crisdesalazine, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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