Structure
CPI-455 Biochemical
CPI-455
Purity
>=98% by HPLC
Synonyms
CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4; 7-dihydropyrazolo[1; 5-a]pyrimidine-3-carbonitrile; CPI-455 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
White to off-white solid
Solubility
DMSO
Molecular Formula
C??H??N?O
CAS Number
1628208-23-0
PubChem CID
78426698
SMILES
CC (C)C1=C (N=C2C (=CNN2C1=O)C#N)C3=CC=CC=C3
InChi
InChI=1S/C16H14N4O/c1-10 (2)13-14 (11-6-4-3-5-7-11)19-15-12 (8-17)9-18-20 (15)16 (13)21/h3-7,9-10,18H,1-2H3
InChi Key
VGXRQCOVGLGFIM-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Protect from air and light
Shelf life: ~36 months
Structure
Structure
Related Product Information for CPI-455 biochemical
CPI-455 is a potent and selective KDM5A inhibitor (IC50 ~10 nM). It inhibits KDM5A, KDM5B and KDM5C to similar extents but shows substantially weaker potency toward KDM4C and KDM7B (~200- and 770-fold, respectively) and no detectable inhibition of KDM2B, KDM3B or KDM6A. It specifically alters H3K4 methylation in cells and binds at the demethylase active site. CPI-455-mediated KDM5 inhibition leads to a dose-dependent increase in global H3K4me3 in HeLa cells, and the removal of CPI-455 resulted in a rapid reversal of H3K4me3 increases in HeLa cells.
Product Categories/Family for CPI-455 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/78426698
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Product Notes
The CPI-455 (Catalog #AAA848179) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CPI-455, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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