Structure
CHF5074 Biochemical
CHF5074
Purity
>98% (HPLC)
Synonyms
CHF5074; CHF-5074; CHF 5074; CSP-1103; CHF5074 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=37mg/mL (113.79mM)
Target
EGFR
Receptor
Beta Amyloid; gamma secretase
Chemical Name
1-[4-(3, 4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid
SMILES
Clc1cc(c2c(F)cc(C3(CC3)C(=O)O)cc2)ccc1Cl
Molecular Formula
C16H11Cl2FO2
CAS Number
749269-83-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CHF5074 biochemical
CHF-5074, also known as CSP-1103, is a gamma-secretase modulator. CHF-5074 reduces Abeta42 and Abeta40 secretion, with an IC50 of 3.6 and 18.4uM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
Product Categories/Family for CHF5074 biochemical
References
1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec; 323 (3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014; 11 (7):714-24.
Similar Products
Product Notes
The CHF5074 (Catalog #AAA3607582) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CHF5074, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
