CHD-5 biochemical

CHD-5

Cat. Num. AAA843035

• Gene Names: CHD5; CHD-5
• Purity: >=98% by HPLC
• Synonyms: CHD-5; N-[2-Methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-2-furancarboxamide; CHD-5 biochemical

• Purity/Purification: >=98% by HPLC
• Form/Format: Appearance: Light orange to dark orange solid
• Sequence Length: 1954

• CAS Number: 289494-16-2
• Structure Available?: Y
• Salt Form: No
• Cell-Permeable?: Yes
• MDL Number: MFCD00389735
• PubChem CID: 2827423
• Solubility/Reconstitution Instructions: DMSO (>15 mg/ml)
• SMILES: CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=CO3)C
• InChi: InChI=1S/C19H17N3O2/c1-13-6-3-4-7-17(13)22-21-15-9-10-16(14(2)12-15)20-19(23)18-8-5-11-24-18/h3-12H,1-2H3,(H,20,23)
• InChi Key: RDQWQMVBBQKHGH-UHFFFAOYSA-N
• Handling: Protect from air and light
• Preparation and Storage: At -20 degree C; Shelf Life: 36 months

Structure

Related Product Information for CHD-5 biochemical

Background: CHD-5 is a potent aryl hydrocarbon receptor (AhR) antagonist.

Product Categories/Family for CHD-5 biochemical

Enzyme Inhibitors; Other Inhibitors; Other InhibitorsBiochemicals; Enzyme Inhibitors; Other Inhibitors; Other InhibitorsBiochemicals; Biochemicals (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 24308089
• NCBI GeneID: 26038
• NCBI Accession #: NP_056372.1
• NCBI GenBank Nucleotide #: NM_015557.2
• Molecular Weight: 319.36
• NCBI Official Full Name: chromodomain-helicase-DNA-binding protein 5
• NCBI Official Synonym Full Names: chromodomain helicase DNA binding protein 5
• NCBI Official Symbol: CHD5
• NCBI Official Synonym Symbols: CHD-5
• NCBI Protein Information: chromodomain-helicase-DNA-binding protein 5
• UniProt Protein Name: Chromodomain-helicase-DNA-binding protein 5
• UniProt Gene Name: CHD5
• UniProt Synonym Gene Names: CHD-5
• UniProt Entry Name: CHD5_HUMAN

NCBI Description

This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]

Uniprot Description

CHD-5: May play a role in the development of the nervous system and the pathogenesis of neural tumors. Belongs to the SNF2/RAD54 helicase family.

Protein type: Helicase; Tumor suppressor; DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 1p36.31

Cellular Component: heterochromatin; membrane; NuRD complex; nucleus

Molecular Function: DNA binding; zinc ion binding; ATP-dependent helicase activity; ATP binding

Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; spermatogenesis, exchange of chromosomal proteins; cerebral cortex neuron differentiation