Structure
BIIB 021 biochemical
BIIB 021
Purity
>=99% by HPLC
Synonyms
BIIB 021; 6-Chloro-9-[(4-methoxy-3; 5-dimethyl--2-pyridinyl)methyl]-9H-purin-2-amine; CNF2024; BIIB 021 biochemical
Purity/Purification
>=99% by HPLC
Form/Format
Appearance: White to off-white solid
CAS Number
848695-25-0
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD15528939
PubChem CID
16736529
Solubility/Reconstitution Instructions
DMSO (~65 mg/ml) or EtOH (~3 mg/ml)
SMILES
CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
InChi
InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)
InChi Key
QULDDKSCVCJTPV-UHFFFAOYSA-N
Handling
Protect from light and moisture
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Shelf Life: 36 months
Structure
Structure
Related Product Information for BIIB 021 biochemical
Background: A synthetic, small molecule Hsp90 inhibitor that binds competitively with geldanamycin in the ATP-binding pocket of Hsp90. In tumor cells, BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and up-regulates expression of the heat shock proteins Hsp70 and Hsp27. BIIB021 inhibits the proliferation of N87, MCF-7, and BT474 tumor cells with IC?? values of 0.06, 0.31, and 0.14 uM, respectively.
Product Categories/Family for BIIB 021 biochemical
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Product Notes
The BIIB 021 (Catalog #AAA842688) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIIB 021, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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