Structure
Bardoxolone Biochemical
Bardoxolone
Purity
>98% (HPLC)
Synonyms
Bardoxolone; CDDO; RTA 401; RTA-401; RTA401; Bardoxolone biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 100mg/mL (203.39mM)
Target
Wee1
Receptor
Nrf2
Chemical Name
(4aS, 6aR, 6bS, 8aR, 12aS, 14aR, 14bS)-11-cyano-2, 2, 6a, 6b, 9, 9, 12a-heptamethyl-10, 14-dioxo-1, 3, 4, 5, 6, 6a, 6b, 7, 8, 8a, 9, 10, 12a, 14, 14a, 14b-hexadecahydropicene-4a(2H)-carboxylic acid
SMILES
C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C1[C@]2(CC[C@@H]2[C@@]1(C=C(C(=O)C2(C)C)C#N)C)C)(C)C)C(=O)O
Molecular Formula
C31H41NO4
CAS Number
218600-44-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Bardoxolone biochemical
CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-gamma-activated mouse macrophages with an IC50value of 0.4nM. By suppressing reactive oxygen and nitrogen species (ROS/RNS) formation, it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various Y cell lines, CDDO has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor gamma, and also that it induces genes regulated by Nrf2, including heme oxygenase-1 and eotaxin-1, which play a role in antioxidant response element signaling activity.
Product Categories/Family for Bardoxolone biochemical
References
1. Reisman SA, et al. J Am Soc Nephrol. 2012 Oct; 23 (10):1663-73.
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Product Notes
The Bardoxolone (Catalog #AAA3607432) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bardoxolone, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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