Structure
Ansamitocin P-3 Biochemical
Ansamitocin P-3
Purity
>98% (HPLC)
Synonyms
Ansamitocin P-3; Maytansinol butyrate; Ansamitocin P-3 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
ADC Cytotoxin
Receptor
microtubule
Chemical Name
Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)C)OC)(NC(=O)O2)O
Molecular Formula
C32H43ClN2O9
CAS Number
66547-09-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ansamitocin P-3 biochemical
A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
Product Categories/Family for Ansamitocin P-3 biochemical
References
1. Ootsu K, et al. Cancer Res. 1980 May; 40 (5):1707-17.
2. Venghateri JB, et al. PLoS One. 2013 Oct 4; 8 (10):e75182.
3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep; 63 (9):925-38.
2. Venghateri JB, et al. PLoS One. 2013 Oct 4; 8 (10):e75182.
3. Martin K, et al. Cancer Immunol Immunother. 2014 Sep; 63 (9):925-38.
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Product Notes
The Ansamitocin P-3 (Catalog #AAA3605534) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ansamitocin P-3, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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