Structure
4-Octyl itaconate Biochemical
4-Octyl itaconate
Purity
>=98%
Synonyms
4-Octyl itaconate; 2-methylene-butanedioic acid; 4-octyl ester; 4-Octyl itaconate biochemical
Purity/Purification
>=98%
Form/Format
Crystalline solid
Solubility
DMSO (~30 mg/ml)
Molecular Formula
C??H??O?
CAS Number
3133-16-2
PubChem CID
71360202
SMILES
CCCCC (CCC)OC (=O)C (=C)CC (=O)[O-]
InChi
InChI=1S/C13H22O4/c1-4-6-8-11 (7-5-2)17-13 (16)10 (3)9-12 (14)15/h11H,3-9H2,1-2H3, (H,14,15)/p-1
InChi Key
GIRJEIMINMHXQS-UHFFFAOYSA-M
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Protect from air and light
Shelf life: ~36 months
Structure
Structure
Related Product Information for 4-Octyl itaconate biochemical
4-Octyl itaconate is an endogenous metabolite of itaconate that activates the anti-inflammatory transcription factor Nrf2 (also known as NFE2L2) by lipopolysaccharide in mouse and human macrophages. Itaconate alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. In vivo, 4-octyl itaconate (50 mg/kg) decreases serum levels of IL-1beta and TNF-alpha, increases Nrf2 protein expression, and protects against LPS-induced lethality in wild-type, but not Nrf2 knockout, mice.
Product Categories/Family for 4-Octyl itaconate biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/71360202
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Product Notes
The 4-Octyl itaconate (Catalog #AAA848451) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "4-Octyl itaconate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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