Testing Data
(Methanesulfonothioic Acid S-(2-Aminoethyl) Ester Hydrochloride; MTSEA-Chloride)
2-Aminoethyl Methanethiosulfonate, Hydrochloride Biochemical
2-Aminoethyl Methanethiosulfonate, Hydrochloride (MTSEA-Chloride)
Synonyms
2-Aminoethyl Methanethiosulfonate; Hydrochloride; Hydrochloride (MTSEA-Chloride); Hydrochloride biochemical
Molecular Formula
C3H9NO2S2• HCl
Melting Point
145-147 degree C
Solubility
DMSO, Warm Ethanol, Methanol, Water,
Preparation and Storage
Some methanethiosulfonates are hygroscopic and all hydrolyze in water, over a period of time, particularly in the presence of nucleophiles. They should be stored in a desiccator at minus 20 degree C and warmed up to room temperature before opening the vial. For maximum results, solutions should be made up immediately prior to use even though solutions in distilled water appear to be stable for hours at 4 degree C.
At pH 7.5 and room temperature, MTSEA hydrolyzes with a half-life of about 15 minutes, MTSET hydrolyzes with a half-life of 10 minutes, and MTSES hydrolyzes with a half-life of 20 minutes. Routinely, one can use 2.5mM MTSEA, 1mM MTSET, or 10mM MTSES, applied for 1 to 5 minutes. (MTSET is 2.5 times as reactive with small sulfhydryl compounds as is MTSEA, and 10 times as reactive as MTSES). (Stauffer and Karlin, 1994; Karlin, personal communication).
For application to Xenopus Oocytes, dissolve the compounds in 115mM NaCl, 2.5mM KCl, 1.8mM MgCl2, 10mM Hepes, pH 7.5 with NaOH. MTS reagents decompose in buffer very quickly.
•DMSO is a good solvent for the MTS reagents which are not water soluble (i.e. the non-charged MTS reagents).
At pH 7.5 and room temperature, MTSEA hydrolyzes with a half-life of about 15 minutes, MTSET hydrolyzes with a half-life of 10 minutes, and MTSES hydrolyzes with a half-life of 20 minutes. Routinely, one can use 2.5mM MTSEA, 1mM MTSET, or 10mM MTSES, applied for 1 to 5 minutes. (MTSET is 2.5 times as reactive with small sulfhydryl compounds as is MTSEA, and 10 times as reactive as MTSES). (Stauffer and Karlin, 1994; Karlin, personal communication).
For application to Xenopus Oocytes, dissolve the compounds in 115mM NaCl, 2.5mM KCl, 1.8mM MgCl2, 10mM Hepes, pH 7.5 with NaOH. MTS reagents decompose in buffer very quickly.
•DMSO is a good solvent for the MTS reagents which are not water soluble (i.e. the non-charged MTS reagents).
Testing Data
(Methanesulfonothioic Acid S-(2-Aminoethyl) Ester Hydrochloride; MTSEA-Chloride)
Testing Data
(Methanesulfonothioic Acid S-(2-Aminoethyl) Ester Hydrochloride; MTSEA-Chloride)
Related Product Information for 2-Aminoethyl Methanethiosulfonate, Hydrochloride biochemical
Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. Useful for mapping the pore-lining regions of the ryanodine receptor.
Product Categories/Family for 2-Aminoethyl Methanethiosulfonate, Hydrochloride biochemical
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Product Notes
The 2-Aminoethyl Methanethiosulfonate, Hydrochloride (Catalog #AAA6048181) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "2-Aminoethyl Methanethiosulfonate, Hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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