Beta-hexatoxin-Mr1a Recombinant Protein | Beta-HXTX-Mr1a recombinant protein
Recombinant Macrothele raveni Beta-hexatoxin-Mr1a
NCBI and Uniprot Product Information
Uniprot Description
Function: Insect and vertebrate active toxin. Binds at site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian rNav1.2a (SCN2A) channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected. Causes temporary paralysis when injected into lepidopteran larvae at 8.6 nmol/g. A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating. A high injection dose causes extensive lacrimation and death.
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed by the venom gland.
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin
By similarity.
Miscellaneous: The primary structure of the mature toxin is identical to that of beta-hexatoxin-Mg1a (Magi-5) from Macrothele gigas (AC P83561).
Sequence similarities: Belongs to the magi-5 family.
Mass spectrometry: Molecular mass is 3287.58 Da from positions 1 - 29. Determined by MALDI. Ref.1
Similar Products
Product Notes
The Beta-hexatoxin-Mr1a beta-hxtx-mr1a (Catalog #AAA1094512) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-29aa; Cytoplasmic domain. The amino acid sequence is listed below: GCKLTFWKCK NKKECCGWNA CALGICMPR. It is sometimes possible for the material contained within the vial of "Beta-hexatoxin-Mr1a, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
